UROCINASE IMMOBILIZED ON FIBRINOGEN

PCT No. PCT/US84/00008 Sec. 371 Date Jan. 3, 1985 Sec. 102(e) Date Jan. 3, 1985 PCT Filed Mar. 1, 1984 PCT Pub. No. WO84/04536 PCT Pub. Date Nov. 22, 1984.Urokinase derivatives comprise urokinase covalently bonded with fibrinogen or urokinase covalently bonded with fibrinogen through an aliphatic di...

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Hauptverfasser:	MAKSIMENKO A.V.,SU, TISHCHENKO E.G.,SU, CHAZOV E.I.,SU, TORCHILIN V.P.,SU, SMIRNOV V.N.,SU
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Zusammenfassung:	PCT No. PCT/US84/00008 Sec. 371 Date Jan. 3, 1985 Sec. 102(e) Date Jan. 3, 1985 PCT Filed Mar. 1, 1984 PCT Pub. No. WO84/04536 PCT Pub. Date Nov. 22, 1984.Urokinase derivatives comprise urokinase covalently bonded with fibrinogen or urokinase covalently bonded with fibrinogen through an aliphatic diamine and correspond to the general formula: wherein P is fibrinogen, E is urokinase, R is absent or stands for wherein n is 1-12, with a molecular mass of from 360,000 to 440,000 D, a content of protein of 10 to 30% by mass, an esterase catalytic activity of 30-60%. These derivatives have an increased affinity to fibrin and feature a prolonged fibrinolytic effect.