Novel 2H-pyridazine-3-one derivatives, pharmaceutical compositions containing same and a process for the preparation of the active ingredient

Novel 2H-pyridazine-3-one derivatives, pharmaceutical compositions containing same and a process for the preparation of the active ingredient

The invention refers to novel 2H-pyridazine-3-one derivatives of the formula I, pharmaceutical compositions containing the same and a process for the preparation of the active ingredient. The novel compounds possess neuroleptic effect and can be used, primarily, for the treatment of schizophrenia. I...

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Hauptverfasser: EGYED ANDRAS, SZENASI GABOR, RACZNE BAJNOGEL JUDIT, SCHMIDT EVA, BARKOCZY JOZSEF, GACSALYI ISTVAN, KOTAY NAGY PETER, PALLAGI KATALIN, LEVAY GYORGY, SIMIG GYULA, MIKLOSNE KOVACS ANIKO, WELLMANN JANOS
Format: Patent
Sprache:eng
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Zusammenfassung:The invention refers to novel 2H-pyridazine-3-one derivatives of the formula I, pharmaceutical compositions containing the same and a process for the preparation of the active ingredient. The novel compounds possess neuroleptic effect and can be used, primarily, for the treatment of schizophrenia. In formula I, R stands for a hydrogen atom or a C1-4, alkyl group, X and Y represent, independently, a hydrogen atom, a halogen atom or a group of the formula II, with the proviso that one of X and Y means always a group of the formula II, and then the other one stands for a hydrogen atom or a halogen atom, wherein in formula II n has a value of 1 or 2.