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A library comprising a multiplicity of solid phase supports, wherein a single peptide species is attached to each solid phase support, and in which the library is prepared by a method comprising repeating k times, wherein k is at least three, the steps of: (i) providing at least two aliquots of a so...

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Bibliographische Detailangaben
Hauptverfasser:	HRUBY VIKTOR J, HERSH EVAN M, SALMON SYDNEY E, AL-OBEIDI FAHRAD, LAM KITSANG
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMBINATORIAL CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS SUGARS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	A library comprising a multiplicity of solid phase supports, wherein a single peptide species is attached to each solid phase support, and in which the library is prepared by a method comprising repeating k times, wherein k is at least three, the steps of: (i) providing at least two aliquots of a solid phase support said supports having an N reactive site; (ii) separately introducing a species of subunit of the peptides to each of the aliquots of solid phase supports such that a different subunit is introduced into each aliquot, said subunit having an N-blocking group and at least one of said subunits having a protecting group or a plurality of protecting groups; (iii) completely covalently coupling the subunit to substantially all the reactive sites of the solid phase support; (iv) thoroughly mixing and removing the N-blocking groups of the aliquots of the solid phase supports whereby an N reactive site is provided; and after repeating steps ii through (iv) k times, a final step of removing any protecting groups such that the protected peptides remain covalently attached to the solid phase supports.