WATER-SOLUBLE NIMESULIDE SALT, PREPARATION METHOD THEREOF, ITS WATER SOLUTION, NIMESULIDE BASED COMBINATIONS AND THEIR USE
Nimesulide, also known under the name of N-(4-nitro-2-phenoxyphenyl)methanesulfonamide or 4-nitro-2-phenoxymethanesulfonanilide which is highly soluble in water, which can be used especially for the preparation of drinkable or injectable solutions of nimesulide while preserving the pharmacological a...
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| creator | PIROTTE BERNARD GECZY JOSZEF PIEL GERALDINE DELNEUVILLE ISABELLE NEVEN PHILIPPE |
| description | Nimesulide, also known under the name of N-(4-nitro-2-phenoxyphenyl)methanesulfonamide or 4-nitro-2-phenoxymethanesulfonanilide which is highly soluble in water, which can be used especially for the preparation of drinkable or injectable solutions of nimesulide while preserving the pharmacological and/or therapeutic antiinflammatory applications of acidic nimesulide. It can be found in the form of a water-soluble nimesulide salt consisting of the reaction product of nimesulide and L-lysine but also as an aqueous solution or the combination based on nimesulide which enhance nimesulide water-solubility compared to nimesulide-L-lysine salt. Therefore nimesulide and L-lysine are combined with at least one cyclodextrin. A pharmaceutical composition comprises an effective quantity of the nimesulide salt in combination with at least one excipient. Said water-soluble nimesulide salt, aqueous solution thereof, combination or pharmaceutical preparation containing it are employed in the treatment of inflammatory diseases. |
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It can be found in the form of a water-soluble nimesulide salt consisting of the reaction product of nimesulide and L-lysine but also as an aqueous solution or the combination based on nimesulide which enhance nimesulide water-solubility compared to nimesulide-L-lysine salt. Therefore nimesulide and L-lysine are combined with at least one cyclodextrin. A pharmaceutical composition comprises an effective quantity of the nimesulide salt in combination with at least one excipient. 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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY COMPOSITIONS BASED THEREON COMPOSITIONS OF MACROMOLECULAR COMPOUNDS DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY ORGANIC MACROMOLECULAR COMPOUNDS POLYSACCHARIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR PREPARATION OR CHEMICAL WORKING-UP |
| title | WATER-SOLUBLE NIMESULIDE SALT, PREPARATION METHOD THEREOF, ITS WATER SOLUTION, NIMESULIDE BASED COMBINATIONS AND THEIR USE |
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