Lactam compound to inhibit beta-amyloid peptide release or synthesis

The present invention provides the compound (N)-((S)-2- hydroxy-3-methyl-butyryl)-1-(L-alaninyl)-(S)-1-amino-3-methyl- 4,5,6,7-tetrahydro-2H-3-benzazepin-2-one, compositions thereof, and use of the compound in the treatment, prevention and inhibiting the progression of Alzheimer's disease. The...

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Bibliographische Detailangaben
Hauptverfasser:	THORSETT EUGENE D, AUDIA JAMES EDMUND, LATIMER LEE H, MCDANIEL STACEY LEIGH, NISSEN JEFFREY SCOTT, JOHN VARGHESE, TUNG JAY S
Format:	Patent
Sprache:	eng ; slo
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides the compound (N)-((S)-2- hydroxy-3-methyl-butyryl)-1-(L-alaninyl)-(S)-1-amino-3-methyl- 4,5,6,7-tetrahydro-2H-3-benzazepin-2-one, compositions thereof, and use of the compound in the treatment, prevention and inhibiting the progression of Alzheimer's disease. The present invention provides the compound (N)-((S)-2- hydroxy-3-methyl-butyryl)-1-(L-alaninyl)-(S)-1-amino-3-methyl- 4,5,6,7-tetrahydro-2H-3-benzazepin-2-one, compositions thereof, and use of the compound in the treatment, prevention and inhibiting the progression of Alzheimer's disease.