Inhibitors of biosynthesis of cholesterol and ergosterol, method of preparation and use thereof

Described are N-alkyl substituted pyrrolidin- benzoheterocyclic compounds of the general formula (I), wherein R1 is hydrogen, methyl, ethyl, propyl and allyl, R2 is halogen atom (F, Cl, Br, I), methoxy, nitro, cyano, amino and trifluoromethyl, Y is N or CH and Z is CH2, CH2CH2, CH=CH, O, S, SO, SO2...

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Bibliographische Detailangaben
Hauptverfasser:	SCHMIDTOVA LUDMILA, ZEMANEK MARIAN, KAKALIK IVAN, OREMUS VLADIMIR, FURDIK MIKULAS, POPOVICOVA LUDMILA, FABEROVA VIERA
Format:	Patent
Sprache:	eng ; slo
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Described are N-alkyl substituted pyrrolidin- benzoheterocyclic compounds of the general formula (I), wherein R1 is hydrogen, methyl, ethyl, propyl and allyl, R2 is halogen atom (F, Cl, Br, I), methoxy, nitro, cyano, amino and trifluoromethyl, Y is N or CH and Z is CH2, CH2CH2, CH=CH, O, S, SO, SO2 and NCH3 and their pharmaceutically acceptable salts; a method of preparation thereof and their use as inhibitors of biosynthesis of cholesterol and ergosterol. Opísané sú substituované N-alkyl pyrolidín-benzoheterocyklické zlúčeniny všeobecného vzorca (I), kde R1 je vodík, metyl, etyl, propyl a alyl, R2 je halogén (F, Cl, Br, I), metoxy, nitro, kyano, aminoa trifluórmetyl, Y je N alebo CH a Z je CH2, CH2CH2, CH=CH, O, S, SO, SO2 a NCH3 a ich farmaceuticky akceptované adičné soli; spôsob ich prípravy a ich použitie ako inhibítorov biosyntézy cholesterolu a ergosterolu.