Fusion protein with specific bond to human interleukin-4, nucleic acid molecule, monoclonal antibodies, pharmaceutical composition and their use

A fusion protein having binding specificity for human interleukin-4 (IL-4) which comprises complementarity determining regions (CDRs) derived from a non-human neutralizing monoclonal antibody with a dissociation constant equal to or less than 2.10exp(-10) M, and a first fusion partner. A nucleic aci...

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Bibliographische Detailangaben
Hauptverfasser:	HOLMES STEPHEN DUDLEY, SYLVESTER DANIEL R, GROSS MITCHELL STUART
Format:	Patent
Sprache:	eng ; slo
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS SUGARS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	A fusion protein having binding specificity for human interleukin-4 (IL-4) which comprises complementarity determining regions (CDRs) derived from a non-human neutralizing monoclonal antibody with a dissociation constant equal to or less than 2.10exp(-10) M, and a first fusion partner. A nucleic acid molecule encoding a fusion protein, monoclonal antibodies, pharmaceutical compositions comprising its and their use. Fúzny proteín so špecifickou väzbou na ľudský interleukín-4 (IL4), obsahujúci komplementárnosť určujúce oblasti (CDRs), odvodené z neutralizačnej monoklonálnej protilátky, nepochádzajúcej od človeka,s disociačnou konštantou rovnajúcou sa alebo menšou ako 2.10-10 M pre IL4 človeka, a prvým fúznym partnerom. Molekula nukleovej kyseliny kódujúca fúzny proteín, monoklonálne protilátky, farmaceutickékompozície s ich obsahom a ich použitie.