Azabenzimidazole-based compounds for modulating serine/threonine protein kinase function

An azabenzimidazole compound having a structure set forth in formula (I), (II) or (III) wherein general symbols have the meaning stated in claims, a method of its synthesizing and its use for the manufacture of a medicament for the treatment of conditions associated with the modulating of the functi...

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Bibliographische Detailangaben
Hauptverfasser:	KUTSCHER BERNHARD, MCMAHON GERALD, APP HARALD, WEINBERGER HEINZ
Format:	Patent
Sprache:	eng ; slo
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	An azabenzimidazole compound having a structure set forth in formula (I), (II) or (III) wherein general symbols have the meaning stated in claims, a method of its synthesizing and its use for the manufacture of a medicament for the treatment of conditions associated with the modulating of the function of a serine/threonine protein kinase, cancer, a fibrotic disorder and a condition associated with an aberration in the signal transduction pathway, which is characterized by an interaction between the serine/threonine protein kinase RAF and a natural binding partner. A pharmaceutical composition comprising an azabenzimidazole compound. Azabenzimidazolová zlúčenina všeobecného vzorca (I), (II) alebo (III), kde všeobecné symboly majú význam uvedený v nárokoch, spôsob jej syntézy a použitie na výrobu liečiva na liečenie stavov spojených s moduláciou funkcie serín/treonín proteín kinázy, nádorového ochorenia, fibrotickej poruchy a iných proliferačných porúch, ako aj stavov spojenýchs aberáciou v dráhe signálovej transdukcie, ktoráje charakterizovaná interakciou medzi serín/treonín proteín kinázou RAF a prirodzeným väzbovým partnerom. Farmaceutická kompozícia s obsahom tejto zlúčeniny.