Pseudopolymorphic forms of 2-[2-[4-[bis(4-fluorophenyl)methyl]- 1-piperazinyl]ethoxy]acetic acid dihydrochloride, their preparation method and pharmaceutical compositions containing them
The present invention relates to new pseudopolymorphic forms of 2-[2-[4-[bis(4-fluorophenyl)methyl]-1- piperazinyl]ethoxy]acetic acid dihydrochloride, namely, anhydrous 2-[2-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride and 2-[2-[4-[bis(4-fluorophenyl)methyl]-1- pip...
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| Format: | Patent |
| Sprache: | eng ; slo |
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| Zusammenfassung: | The present invention relates to new pseudopolymorphic forms of 2-[2-[4-[bis(4-fluorophenyl)methyl]-1- piperazinyl]ethoxy]acetic acid dihydrochloride, namely, anhydrous 2-[2-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride and 2-[2-[4-[bis(4-fluorophenyl)methyl]-1- piperazinyl]ethoxy]acetic acid dihydrochloride monohydrate. It also relates to processes for the preparation of these pseudopolymorphic forms and to pharmaceutical compositions containing them.
Sú opísané polymorfné formy dihydrochloridu kyseliny 2-[2-[4-[bis(4-fluórfenyl)metyl]-1-piperazinyl]etoxy]octovej, totiž bezvodého dihydrochloridu kyseliny 2-[2-[4-[bis(4-fluórfenyl)metyl]-1-piperazinyl]etoxy]octovej a monohydrátu dihydrochloridu kyseliny 2-[2-[4-[bis(4-fluórfenyl)metyl]-1-piperazinyl]etoxy]octovej. Tiež je opísaný spôsob prípravy týchto pseudopolymorfných foriem a farmaceutické kompozície, ktoré ich obsahujú.ŕ |
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