PROCESS FOR THE SYNTHESIS OF 2,6-DICHLORO-5-FLUORONICOTINIC ACID AND 2,6-DICHLORO-5-FLUORONICOTINOYL CHLORIDE
An improved process for the preparation of 2,6-dichloro-5- -fluoronicotinoyl chloride is described where a 2,6-dihydroxy- -5-fluoronicotinic acid ester is converted in one step using phosphorus oxychloride and a lithium reagent to 2,6-dichloro- -5-fluoronicotinoyl chloride and subsequent basic hydro...
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| Format: | Patent |
| Sprache: | eng ; slo |
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| Zusammenfassung: | An improved process for the preparation of 2,6-dichloro-5- -fluoronicotinoyl chloride is described where a 2,6-dihydroxy- -5-fluoronicotinic acid ester is converted in one step using phosphorus oxychloride and a lithium reagent to 2,6-dichloro- -5-fluoronicotinoyl chloride and subsequent basic hydrolysis affords 2,6-dichloro-5-fluoronicotinic acid.
Spôsob prípravy kyseliny 2,6-dichlór-5-fluórnikotínovej, zahrňujúcej reakciu esteru kyseliny 2,6-dihydroxy-5- -fluórnikotínovej s POCl3 v prítomnosti lítneho reakčného činidla za vzniku 2,6-dichlór-5-fluórnikotinoylchloridu a následnou zásaditou hydrolýzou uvedeného produktu sa získa kyselina 2,6-dichlór-5-fluórnikotínová.ŕ |
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