DERIVATIVES OF 1,3-DIHYDRO-2H-PYRROLO[2,3-B]QUINOLIN-2-ONE, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS BASED THEREON

There are dislosed positive inotropic and lusitropic derivatives of 1,3-dihydro-2h-pyrrolo[2,3-b]quinolin-2-one of the general formula (I) wherein L is a formula -O-Alk-(NH)p-C(=O)-R1, Alk C1-6 alkanediyl; p is 0 or 1; and R1 is OH, C1-4 alkoxy or -NR2R3, wherein R2 is H or C1-4 alkyl; and R3 is C3-7 cycloalkyl or piperidinyl, which is optionally substituted with C1-4 alkyl or phenylmethyl or C3-7 cycloalkylmethyl; R2 and R3 may also be joined together to form piperazinyl, optionally substituted with C3-7 cycloalkyl, C3-7 cycloalkylmethyl, C1-6 alkyl optionally substituted with one or two hydroxy groups, 2,2-dimethyl-1,3-dioxolanylmethyl, benzyl, halophenylmethyl, (cyclopentyloxy)(methoxy)phenylmethyl, diphenylC1-4 alkyl, pyridinyl, pyrimidinyl or phenyl optionally substituted with C1-4 alkyloxy or halo; or R2 and R3 are joined together to form piperidinyl, optionally substituted with imidazolylcarbonyl; and pharmaceutically acceptable addition salt thereof or a stereochemically isomeric form thereof; a process and intermediates for their preparation; pharmaceutical compositions on their basis.