PROCESS FOR THE PREPARATION OF 4-METHYL-5-(2-CHLOROALKYL)THIAZOLE

PROCESS FOR THE PREPARATION OF 4-METHYL-5-(2-CHLOROALKYL)THIAZOLE

The present invention relates to a process for the preparation of a 4-methyl-5-(2-chloroalkyl)thiazole derivative of general formula (I), wherein R stands for a straight chained C2-5alkyl group substituted by a chlorine atom in the 2-position, and acid addition salts thereof, characterised by reacti...

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Hauptverfasser: MOLNAR ERZSEBET, GONCZI CSABA, SUTO MIHALY, SPERBER FERENC, BAN KAROLY, MORASZ FERENC, GARACZY SANDOR, PALOSI ENDRE, KORBONITS DEZSO, KISS PAL, SZABO ERZSEBET, NEMETH ATTILA, GYURE KAROLY, BUTTKAI ILDIKO, SZALAY ERZSEBET, GYORI PETER, HEJA GERGELY, HUSZAR CSABA, LEDNICZKY LASZLO, SZVOBODA IDA, MIHALOVICS GYORGY, KOVARI ARPAD, BONE ISTVAN
Format: Patent
Sprache:eng ; slo
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present invention relates to a process for the preparation of a 4-methyl-5-(2-chloroalkyl)thiazole derivative of general formula (I), wherein R stands for a straight chained C2-5alkyl group substituted by a chlorine atom in the 2-position, and acid addition salts thereof, characterised by reacting a 3-thiocyanato-5-chloro-2-alkanone of general formula (IV) with gaseous hydrochloric acid, in an inorganic solvent, at 0-100 degrees Celsius and thus converting thereof into 2-chloro- -4-methyl-5-(2-chloroalkyl)thiazole of general formula (II); hydrogenating the said compound in the presence of a metal catalyst, in an organic solvent, thus obtaining 4-methyl-5-(2-chloroalkyl)thiazole of general formula (I), and optionally converting the general formula (I) compound thus obtained or a hydrochloride salt thereof into another acid addition salt or setting free a compound of general formula (I), wherein R is as defined above, from its acid addition salt.