2-HYDROXYETHYLAMINO SUBSTITUTED DERIVATIVES OF 5,11-DIOXO-5,6- -DIHYDRO-11H-INDENO£1,2-C|ISOQUINOLINE, PRODUCING METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

2-HYDROXYETHYLAMINO SUBSTITUTED DERIVATIVES OF 5,11-DIOXO-5,6- -DIHYDRO-11H-INDENO£1,2-C|ISOQUINOLINE, PRODUCING METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

This patent describes indenoisoquinoline derivatives with a general formula (I), having antitumor effects, where n means the integer variable with the value of 0 up to 5, together with the procedure closed to their preparation based on the condensation of indeno[1,2-c]isocumarin or 1-methoxy-2-(2- -...

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Hauptverfasser: MELKA MILAN, HRUBY MILAN, SKACELOVA EVA, KARGEROVA ANNA, MIKO MILAN, KOLONICNY ALOIS, KREPELKA JIRI, KEJHOVA IRENA, HRBATA JIRI, REICHLOVA RUZENA, FERENC MILAN, MICHALSKY JIRI, SEDIVA JITKA, URBANEC JOSEF
Format: Patent
Sprache:eng ; slo
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:This patent describes indenoisoquinoline derivatives with a general formula (I), having antitumor effects, where n means the integer variable with the value of 0 up to 5, together with the procedure closed to their preparation based on the condensation of indeno[1,2-c]isocumarin or 1-methoxy-2-(2- -methoxycarbonylphenyl)-1-inden-3-one with N-(2- -hydroxyethyl)alkylendiamine, while hot dimethylformamide is present. The next one method closed to the preparation of these compounds is a condensation of 6-(n-chloroalkyl)-5,11- -dioxo-5,6-dihydro-11H-indeno[1,2-c]isoquinolines with ethanolamine, while dimethylformamide and anhydrous potassium carbonate is present. These new derivatives can be applied for preparation of antineoplastic curative facilities used for healing of malign neoplastic mammal diseases.