PYRROLIDINES AS INHIBITORS OF NEURAMINIDASES

PYRROLIDINES AS INHIBITORS OF NEURAMINIDASES

Disclosed are compounds of formula (I) which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes...

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Hauptverfasser: WANG SHELDON, SHAM HING L, GU YU GUI, XU YIBO, MUCHMORE STEVEN W, ZHAO CHEN, MADIGAN DAROLD L, DEGOEY DAVID A, KATI WARREN M, STOLL VINCENT S, CHEN YUANWEI, KENNEDY APRIL, MARING CLARENCE J, SUN MINGHUA, WANG GARY T, GRAMPOVNIK DAVID J, KLEIN LARRY L, LIN ZHEN, GIRANDA VICENT L, FLOSI WILLIAM J, KRUEGER ALLAN C, MCDANIEL KEITH F, YEUNG MING C, KEMPF DALE J, CHEN HUI-JU, STEWART KENT D
Format: Patent
Sprache:eng ; slo
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Disclosed are compounds of formula (I) which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.