A PROCESS FOR THE PREPARATION OF QUETIAPINE AND INTERMEDIATES THEREFOR

A PROCESS FOR THE PREPARATION OF QUETIAPINE AND INTERMEDIATES THEREFOR

The invention refers to a novel process for the preparation of 11-[4-/2-(2-hydroxyethoxy)ethyl/-1-piperazinyl]dibenzo[b,f]-1,4-thiazepine of the formula (I) known as quetiapine. According to the invention, a haloethylpiperazinylthiazepine derivative of the formula (VIII), wherein Hal stands for a ha...

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Bibliographische Detailangaben
Hauptverfasser: KRASZNAI GYORGY, RAKOCZY GYORGYNE, KOVANYINE LAX GYORGYI, NAGY KALMAN, TOMPE PETER, VERECZKEYNE DONATH GYORGYI, BOZSING DANIEL, SIMIG GYULA
Format: Patent
Sprache:eng ; slo
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Zusammenfassung:The invention refers to a novel process for the preparation of 11-[4-/2-(2-hydroxyethoxy)ethyl/-1-piperazinyl]dibenzo[b,f]-1,4-thiazepine of the formula (I) known as quetiapine. According to the invention, a haloethylpiperazinylthiazepine derivative of the formula (VIII), wherein Hal stands for a halo atom, is reacted with ethylene glycol.