MICROBIAL PROCESS FOR THE PRODUCTION OF IMMUNOSUPPRESIVE ANTIBIOTICS

The invention refers to the microbial process for the production of immunosuppresive cyclosporine antibiotic complex or its components, cyclosporine A, cyclosporine B and cyclosporine C with the help of aerobic fermentation of fibrous fungal strain, where the above antibiotic is biosynthesised on th...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	NAGY KAROLY, SANTHA GYOERGY, KOENCZOEL KALMAN, AMBRUS GABOR, PALOTAS BELA, MORAVCSIK IMRE, HUELBER NEE DOBOS AGOTA, MOLNAR ANTAL ANIKO, ANDOR ATTILA, JEKKEL BOKANY ANTONIA, TOTH-SARUDY EVA, KISS LAJOS, ALBRECHT KAROLY, SZELL VALERIA, POLYA KALMAN, BUZASI KAROLY, SZASZHEGYESI VILMA, ERDEI JANOS, SZABO MIHALY ISTVAN, MAKADI BELA, DELI KONSZKY ETELKA, TOMORI JOSZT EVA
Format:	Patent
Sprache:	eng ; slv
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The invention refers to the microbial process for the production of immunosuppresive cyclosporine antibiotic complex or its components, cyclosporine A, cyclosporine B and cyclosporine C with the help of aerobic fermentation of fibrous fungal strain, where the above antibiotic is biosynthesised on the nutrient medium, which contains useful sources of carbon and nitrogen as well as mineral salts and the resulting products are isolated. This comprises the cultivation of the strain of the new fungal species Tolypocladium varium, so that cyclosporine antibiotic complex is obtained, preferentially Tolypocladium varium sp. nov. CY/93, which is deposited at the National Collection of Agricultural and Industrial Microorganisms, Budapest, Hungary, under the number NCAIM(P)F 001005, on the nutrient medium which contains the sources of carbon, organic and inorganic sources of nitrogen, as well as mineral salts under aerobic conditions, at 25 to 30 degrees Centigrade and, if desired, the isolation and purification of cyclosporine antibiotic complex or its resulting components. The invention refers to the microbial process for the production of immunosuppresive cyclosporine antibiotic complex or its components, cyclosporine A, cyclosporine B and cyclosporine C with the help of aerobic fermentation of fibrous fungal strain, where the above antibiotic is biosynthesised on the nutrient medium, which contains useful sources of carbon and nitrogen as well as mineral salts and the resulting products are isolated. This comprises the cultivation of the strain of the new fungal species Tolypocladium varium, so that cyclosporine antibiotic complex is obtained, preferentially Tolypocladium varium sp. nov. CY/93, which is deposited at the National Collection of Agricultural and Industrial Microorganisms, Budapest, Hungary, under the number NCAIM(P)F 001005, on the nutrient medium which contains the sources of carbon, organic and inorganic sources of nitrogen, as well as mineral salts under aerobic conditions, at 25 to 30 degrees Centigrade and, if desired, the isolation and purification of cyclosporine antibiotic complex or its resulting components. Postopek se nanaša na mikrobni postopek za proizvodnjo imunosupresivnega ciklosporinskega antibiotičnega kompleksa ali njegovih komponent, ciklosporina A, ciklosporina B in ciklosporina C, s pomočjo aerobne fermentacije vlaknastega glivičnega seva, pri čemer se biosintetizira gornji antibiotik(e) na hranljivi podlagi, ki vsebuje uporabn