MODULATORS OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN AND METHODS OF USE

The invention discloses compounds of Formula (I):wherein A1, R1, R2, R3, R4, and n are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis and pharmaceutical compositions comprising the same. Also disclosed are methods for their production...

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Hauptverfasser:	PICOLET Olivier Laurent, BOGDAN Andrew, COUTY Sylvain, MERAYO MERAYO Nuria, LIU Bo, PIZZONERO Mathieu Rafael, KYM Philip R, MAI Thi Thu Trang, VAN DER PLAS Steven Emiel, HOUSSEMAN Christopher Gaetan, MALAGU Karine Fabienne, YEUNG Ming C, GFESSER Gregory A, DESROY Nicolas, ALTENBACH Robert J, WANG Xueqing, SEARLE Xenia B
Format:	Patent
Sprache:	eng ; slv
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention discloses compounds of Formula (I):wherein A1, R1, R2, R3, R4, and n are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis and pharmaceutical compositions comprising the same. Also disclosed are methods for their production and methods of treating cystic fibrosis by administering the compounds.