BETA-LACTAMASE INHIBITORS

BETA-LACTAMASE INHIBITORS

This invention pertains generally to compounds of Formula (A),as further described herein, which act as beta-lactamase inhibitors, and salts, crystalline forms and formulations thereof. In certain aspects, the invention pertains to methods of using such compounds in combination with a beta-lactam an...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: RECK Folkert, ZHU Qingming, CASAREZ Anthony, FUREGATI Markus, KOCH Guido, OSSOLA Flavio, LIN Xiaodong, SIMMONS Robert Lowell
Format: Patent
Sprache:eng ; slv
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:This invention pertains generally to compounds of Formula (A),as further described herein, which act as beta-lactamase inhibitors, and salts, crystalline forms and formulations thereof. In certain aspects, the invention pertains to methods of using such compounds in combination with a beta-lactam antibiotic to treat infections caused by Gram-negative bacteria, including drug-resistant strains.