GLUCAGON AND GLP-1 CO-AGONISTS FOR THE TREATMENT OF OBESITY

The present invention provides protease-resistant peptides, methods of making such peptides, as well as compositions comprising protease-resistant peptides and method of treatment utilizing such peptides. Incorporation of alpha-methyl-functionalized amino acids directly into the main chain during st...

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Hauptverfasser: LOFMARK Rasmus Jansson, METCALFE Jaqueline, FAIRMAN David, BEDNAREK Maria A, JACKSON Ronald Henry, AGORAM Balaji, ANTONSSON Madeleine, BURMEISTER Nicole, BENTHEM Lambertus, FRITSCH-FREDIN Maria
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creator LOFMARK Rasmus Jansson
METCALFE Jaqueline
FAIRMAN David
BEDNAREK Maria A
JACKSON Ronald Henry
AGORAM Balaji
ANTONSSON Madeleine
BURMEISTER Nicole
BENTHEM Lambertus
FRITSCH-FREDIN Maria
description The present invention provides protease-resistant peptides, methods of making such peptides, as well as compositions comprising protease-resistant peptides and method of treatment utilizing such peptides. Incorporation of alpha-methyl-functionalized amino acids directly into the main chain during standard peptide synthesis via the methodologies described herein has been determined to produce protease-resistant peptides.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title GLUCAGON AND GLP-1 CO-AGONISTS FOR THE TREATMENT OF OBESITY
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