GLUCAGON AND GLP-1 CO-AGONISTS FOR THE TREATMENT OF OBESITY

The present invention provides protease-resistant peptides, methods of making such peptides, as well as compositions comprising protease-resistant peptides and method of treatment utilizing such peptides. Incorporation of alpha-methyl-functionalized amino acids directly into the main chain during st...

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Bibliographische Detailangaben
Hauptverfasser:	LOFMARK Rasmus Jansson, METCALFE Jaqueline, FAIRMAN David, BEDNAREK Maria A, JACKSON Ronald Henry, AGORAM Balaji, ANTONSSON Madeleine, BURMEISTER Nicole, BENTHEM Lambertus, FRITSCH-FREDIN Maria
Format:	Patent
Sprache:	eng ; slv
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention provides protease-resistant peptides, methods of making such peptides, as well as compositions comprising protease-resistant peptides and method of treatment utilizing such peptides. Incorporation of alpha-methyl-functionalized amino acids directly into the main chain during standard peptide synthesis via the methodologies described herein has been determined to produce protease-resistant peptides.