NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS
The present invention relates novel 6-6 bicyclic aromatic ring substituted nucleoside analogues of Formula (I)wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical...
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| creator | GILISSEN Ronaldus Arnodus Hendrika Joseph BEKE Lijs SUN Weimei VIELLEVOYE Marcel THURING Johannes Wilhelmus John F WU Tongfei BREHMER Dirk SCHEPENS Wim Bert Griet PARADE Marcus Cornelis Bernardus Catharina DIELS Gaston Stanislas Marcella BOECKX An PANDE Vineet LAWSON Edward Charles MEERPOEL Lieven |
| description | The present invention relates novel 6-6 bicyclic aromatic ring substituted nucleoside analogues of Formula (I)wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament. |
| format | Patent |
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The compounds according to the present invention are useful as PRMT5 inhibitors. 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The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS |
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