NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS

The present invention relates novel 6-6 bicyclic aromatic ring substituted nucleoside analogues of Formula (I)wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical...

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Bibliographische Detailangaben
Hauptverfasser:	GILISSEN Ronaldus Arnodus Hendrika Joseph, BEKE Lijs, SUN Weimei, VIELLEVOYE Marcel, THURING Johannes Wilhelmus John F, WU Tongfei, BREHMER Dirk, SCHEPENS Wim Bert Griet, PARADE Marcus Cornelis Bernardus Catharina, DIELS Gaston Stanislas Marcella, BOECKX An, PANDE Vineet, LAWSON Edward Charles, MEERPOEL Lieven
Format:	Patent
Sprache:	eng ; slv
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention relates novel 6-6 bicyclic aromatic ring substituted nucleoside analogues of Formula (I)wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.