PROCESSES FOR PREPARING ASK1 INHIBITORS

PROCESSES FOR PREPARING ASK1 INHIBITORS

The present disclosure provides processes for the preparation of a compound of formula:which exhibits apoptosis signal-regulating kinase ("ASK1") inhibitory activity and is thus useful in the treatment of diseases such as kidney disease, diabetic nephropathy and kidney fibrosis. The disclo...

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Bibliographische Detailangaben
Hauptverfasser: REYNOLDS Troy Evan, CHIU Anna, GRIGGS Nolan, HEUMANN Lars V, NOTTE Gregory, SARMA Keshab, BROWN Brandon Heath, CHAN Brenda J. Burke, THOMPSON Andrew S, WANG Tao, LATHROP Stephen P, SILER David Allen
Format: Patent
Sprache:eng ; slv
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present disclosure provides processes for the preparation of a compound of formula:which exhibits apoptosis signal-regulating kinase ("ASK1") inhibitory activity and is thus useful in the treatment of diseases such as kidney disease, diabetic nephropathy and kidney fibrosis. The disclosure also provides compounds that are synthetic intermediates.