PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE 1-AMINOINDAN

PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE 1-AMINOINDAN

The present invention relates to a process for the preparation of optically pure ( R) -1-aminoindan by a diastereomeric resolution of 1-aminoindan using N-acetyl-L-glutamic acid as a resolving agent. In another aspect, the invention relates to diastereomeric salts of (R) -1-aminoindan with N-acetyl-...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: RUZIC Milos, PRUDIC Darja, PLEVNIK Miha, PECAVAR Anica, KUFNER Monika, KLJAJIC Alen
Format: Patent
Sprache:eng ; slv
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention relates to a process for the preparation of optically pure ( R) -1-aminoindan by a diastereomeric resolution of 1-aminoindan using N-acetyl-L-glutamic acid as a resolving agent. In another aspect, the invention relates to diastereomeric salts of (R) -1-aminoindan with N-acetyl-L-glutamic acid, and their use in the process for the preparation of rasagiline.