Piperidinone derivatives as MDM2 inhibitors for the treatment of cancer
The present invention provides MDM2 inhibitor compounds of Formula IE,which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.
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| creator | Gustin Darin James Sun Daqing Kayser Frank Connors Richard Victor Yu Ming Huang Xin Kopecky David John Liu Jiwen Wang Yingcai Fu Jiasheng Deignan Jeffery McGee Lawrence Johnson Michael Ma Zhihua Roveto Philip Marley Eksterowicz John Fox Brian Matthew Rew Yosup Gribble jr. Michael William Beck Hilary Plake Zhu Jiang Heath Julie Anne Low Jonathan Dante Fisher Benjamin Li Yihong Chen Xiaoqi Bartberger Michael David Duquette Jason McMinn Dustin Jiao Xianjun Wang Xiaodong Yan Xuelei Lai SuJen Gonzalez Buenrostro Ana Gonzalez Lopez de Turiso Felix McIntosh Joel Mihalic Jeffrey Thomas Li Zhihong Fu Zice Olson Steven Howard Lucas Brian Stuart Medina Julio Cesar |
| description | The present invention provides MDM2 inhibitor compounds of Formula IE,which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor. |
| format | Patent |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Piperidinone derivatives as MDM2 inhibitors for the treatment of cancer |
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