Piperidinone derivatives as MDM2 inhibitors for the treatment of cancer

The present invention provides MDM2 inhibitor compounds of Formula IE,which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

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Bibliographische Detailangaben
Hauptverfasser:	Gustin Darin James, Sun Daqing, Kayser Frank, Connors Richard Victor, Yu Ming, Huang Xin, Kopecky David John, Liu Jiwen, Wang Yingcai, Fu Jiasheng, Deignan Jeffery, McGee Lawrence, Johnson Michael, Ma Zhihua, Roveto Philip Marley, Eksterowicz John, Fox Brian Matthew, Rew Yosup, Gribble jr. Michael William, Beck Hilary Plake, Zhu Jiang, Heath Julie Anne, Low Jonathan Dante, Fisher Benjamin, Li Yihong, Chen Xiaoqi, Bartberger Michael David, Duquette Jason, McMinn Dustin, Jiao Xianjun, Wang Xiaodong, Yan Xuelei, Lai SuJen, Gonzalez Buenrostro Ana, Gonzalez Lopez de Turiso Felix, McIntosh Joel, Mihalic Jeffrey Thomas, Li Zhihong, Fu Zice, Olson Steven Howard, Lucas Brian Stuart, Medina Julio Cesar
Format:	Patent
Sprache:	eng ; slv
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides MDM2 inhibitor compounds of Formula IE,which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.