Antibodies that bind cell-associated CA 125/O722P and methods of use thereof

The present invention provides fusion proteins of antibodies, and antigen-binding fragments of antibodies, that preferentially bind cell-associated CA 125/0772P polypeptides relative to shed CA 125/0772P polypeptides. They comprise a heterologous agent such as a detectable agent or a therapeutic agent. The present disclsoure further provides methods of preventing, managing, treating or ameliorating one or more symptoms associated with a CA 125/0772P-related disorder. In particular, the present disclosure provides methods of preventing, managing, treating, or ameliorating one or more symptoms associated with a cell proliferative disorder, such as cancer, e.g., ovarian cancer. The present disclosure still further provides methods for diagnosing a CA 125/0772P-related disorder or predisposition to developing such a disorder, as well as methods for identifying antibodies, and antigen-binding fragments of antibodies, that preferentially bind cell-associated CA 125/0772P polypeptides relative to shed CA 125/0772P polypeptides.