CYCLOPROPANE COMPOUND

A cyclopropane compound represented by the following formula (A) or a pharmaceutically acceptable salt thereof has orexin receptor antagonism, and therefore has a potencial of usefulness for the treatment of sleep disorder for which orexin receptor antagonism is effective, for example, insomnia: whe...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	DOKO TAKASHI, KAZUTA YUJI, NAOE YOSHIMITSU, TAKEMURA AYUMI, YOSHIDA YU, SORIMACHI KEIICHI, TERAUCHI TARO, BEUCKMANN CARSTEN, TANAKA TOSHIAKI
Format:	Patent
Sprache:	eng ; slv
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	A cyclopropane compound represented by the following formula (A) or a pharmaceutically acceptable salt thereof has orexin receptor antagonism, and therefore has a potencial of usefulness for the treatment of sleep disorder for which orexin receptor antagonism is effective, for example, insomnia: wherein Q represents -CH- or a nitrogen atom, R 1a and R 1b each independently represent a C 1-6 alkyl group and the like, R 1c represents a hydrogen atom and the like, R 2a , R 2b , R 2c and R 2d each independently represent a hydrogen atom, a halogen atom, a C 1-6 alkyl group and the like, R 3a , R 3b and R 3c each independently represent a hydrogen atom, a halogen atom and the like, and R 3d represents a hydrogen atom and the like.