2,3 DIHYDRO-1H-INDEN-1-YL-2,7-DIAZASPIRO(3.6)NONANE DERIVATIVES AND THEIR USE AS ANTAGONISTS OR INVERSE AGONISTS OF THE GHRELIN RECEPTOR

2,3 DIHYDRO-1H-INDEN-1-YL-2,7-DIAZASPIRO(3.6)NONANE DERIVATIVES AND THEIR USE AS ANTAGONISTS OR INVERSE AGONISTS OF THE GHRELIN RECEPTOR

The present invention provides a compound of Formula (I) or a pharmaceutically salt thereof wherein R1, R2, Ra, L, Z, Z1 and Z2 are as defined herein, that act as Ghrelin antagonists or inverse agonists; pharmaceutical compositions thereof; and methods of treating diseases, disorders, or conditions...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: CAMERON KIMBERLY O'KEEFE, KUNG DANIEL WEI-SHUNG, FERNANDO DILINIE PRASADHINI, SIMILA SUVI TUULA MARJUKKA, BHATTACHARYA SAMIT KUMAR, MCCLURE KIM FRANCIS, LONDREGAN ALLYN TIMOTHY
Format: Patent
Sprache:eng ; slv
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The present invention provides a compound of Formula (I) or a pharmaceutically salt thereof wherein R1, R2, Ra, L, Z, Z1 and Z2 are as defined herein, that act as Ghrelin antagonists or inverse agonists; pharmaceutical compositions thereof; and methods of treating diseases, disorders, or conditions mediated by the antagonism of the Ghrelin receptor.