SUBSTITUTED ISOQUINOLINONES AND QUINAZOLINONES

The invention relates to substituted nitrogen containing bicyclic heterocycles of the formula (I) wherein Z is CH2 or N-R4 and X, R1, R2, R4, R6, R7 and n are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MD...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	REN HAIXIA, HERGOVICH LISZTWAN JOANNA, JACOBY EDGAR, KALLEN JOERG, HOLZER PHILIPP, BERGHAUSEN JOERG, FURET PASCAL, PISSOT SOLDERMANN CAROLE, GESSIER FRANCOIS, MASUYA KEIICHI, STUTZ STEFAN, BUSCHMANN NICOLE
Format:	Patent
Sprache:	eng ; slv
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to substituted nitrogen containing bicyclic heterocycles of the formula (I) wherein Z is CH2 or N-R4 and X, R1, R2, R4, R6, R7 and n are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof.