SELECTIVE SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS

Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the SIP receptor. Methods of chiral synthesis of such compounds is provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions...

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Hauptverfasser: MARTINBOROUGH Esther, TAMIYA Junko, BOEHM Marcus F, HANSON Michael Allen, HUANG Liming, TIMONY Gregg Alan, SCOTT Fiona Lorraine, YEAGER Adam Richard, BRAHMACHARY Enugurthi, PEACH Robert, MOORJANI Manisha, BROOKS Jennifer L
Format: Patent
Sprache:eng ; slv
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Zusammenfassung:Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the SIP receptor. Methods of chiral synthesis of such compounds is provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.