RESOLUTION OF ( )-METHYL PHENYLS4-S4-SSS4'-(TRIFLUOROMETHYL)-2-BIPHENYLYLCCARBONYLCAMINOCPHENYLC-1-PIPERIDINYLCACETATE

The present invention relates to a resolution process of (±)-methyl phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate to isolate the MTP (microsomal triglyceride transfer protein) inhibitor methyl (2S)-phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphen...

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Hauptverfasser:	COPMANS ALEX HERMAN, VAN DUN JOANNES PETRUS, HOET JEROME ALBERT JOSEPH, COUCK WOUTER LOUIS J, WILLEMSENS ALBERT LOUIS ANNA
Format:	Patent
Sprache:	eng ; slv
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator	COPMANS ALEX HERMAN VAN DUN JOANNES PETRUS HOET JEROME ALBERT JOSEPH COUCK WOUTER LOUIS J WILLEMSENS ALBERT LOUIS ANNA
description	The present invention relates to a resolution process of (±)-methyl phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate to isolate the MTP (microsomal triglyceride transfer protein) inhibitor methyl (2S)-phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate and an epimerisation procedure for racemizing methyl (2R)-phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate.
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subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title	RESOLUTION OF ( )-METHYL PHENYLS4-S4-SSS4'-(TRIFLUOROMETHYL)-2-BIPHENYLYLCCARBONYLCAMINOCPHENYLC-1-PIPERIDINYLCACETATE
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