RESOLUTION OF ( )-METHYL PHENYLS4-S4-SSS4'-(TRIFLUOROMETHYL)-2-BIPHENYLYLCCARBONYLCAMINOCPHENYLC-1-PIPERIDINYLCACETATE

RESOLUTION OF ( )-METHYL PHENYLS4-S4-SSS4'-(TRIFLUOROMETHYL)-2-BIPHENYLYLCCARBONYLCAMINOCPHENYLC-1-PIPERIDINYLCACETATE

The present invention relates to a resolution process of (±)-methyl phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate to isolate the MTP (microsomal triglyceride transfer protein) inhibitor methyl (2S)-phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphen...

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Bibliographische Detailangaben
Hauptverfasser: COPMANS ALEX HERMAN, VAN DUN JOANNES PETRUS, HOET JEROME ALBERT JOSEPH, COUCK WOUTER LOUIS J, WILLEMSENS ALBERT LOUIS ANNA
Format: Patent
Sprache:eng ; slv
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present invention relates to a resolution process of (±)-methyl phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate to isolate the MTP (microsomal triglyceride transfer protein) inhibitor methyl (2S)-phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate and an epimerisation procedure for racemizing methyl (2R)-phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate.