KDR and VEGF/KDR binding peptides and their use in diagnosis

KDR and VEGF/KDR binding peptides and their use in diagnosis

The present invention provides binding polypeptides for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex wit...

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Hauptverfasser: NANJAPPAN PALANIAPPA, NUNN ADRIAN D, SATO AARON K, LADNER ROBERT C, BUSSAT PHILIPPE, DRANSFIELD DANIEL T, MARINELLI EDMUND R, PILLAI RADHAKRISHNA K, SHRIVASTAVA AJAY, YAN FENG, SWENSON ROLF E, FAN HONG, LINDER KAREN E, POCHON SIBYLLE, ARBOGAST CHRISTOPHE, RAMALINGAM KONDAREDDIAR, VON WRONSKI MATHEW A, SONG BO, SEXTON DANIEL J
Format: Patent
Sprache:eng ; slv
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:The present invention provides binding polypeptides for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity ( e.g ., having a K D < 1 µM).