PAN-KIR2DL NK-RECEPTOR ANTIBODIES AND THEIR USE IN DIAGNOSTIK AND THERAPY

PAN-KIR2DL NK-RECEPTOR ANTIBODIES AND THEIR USE IN DIAGNOSTIK AND THERAPY

Compositions and methods for regulating an immune response in a subject are described. More particularly, described are human antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects, and antibodies having antigen-binding properties sim...

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Bibliographische Detailangaben
Hauptverfasser: Berg Padkaer Soren, Zahn Stefan, Svendsen Ivan, Romagne Francois, Spee Pieter, Gauthier Laurent, Thorolfsson Matthias, Della Chiesa Mariella, Andre Pascale, Wilken Michael, Moretta Alessandro, Wagtmann Peter Andreas Nicolai Reumert, Svensson Anders, Kjaergaard Kristian
Format: Patent
Sprache:eng ; slv
Schlagworte:
CHEMISTRY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
TESTING
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Beschreibung
Zusammenfassung:Compositions and methods for regulating an immune response in a subject are described. More particularly, described are human antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects, and antibodies having antigen-binding properties similar to those of human monoclonal antibody 1-7F9 or 14F1. Described also are fragments and derivatives of such antibodies, as well as pharmaceutical compositions comprising the same and their uses, particularly for use in therapy, to increase NK cell activity or cytotoxicity in subjects.