THIAZOLOPYRIDIN-2-YLOXY-PHENYL AND THIAZOLOPYRAZIN-2-YLOXY-PHENYL AMINES AS MODULATORS OF LEUKOTRIENE A4 HYDROLASE

THIAZOLOPYRIDIN-2-YLOXY-PHENYL AND THIAZOLOPYRAZIN-2-YLOXY-PHENYL AMINES AS MODULATORS OF LEUKOTRIENE A4 HYDROLASE

Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, an...

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Hauptverfasser: DENG XIAOHU, LOCHNER SUSANNE, ZINSER HARTMUT, FOURINE ANNE M, SAPPEY KATHLEEN C, LANDRY-BAYLE ADRIENNE M, CHEUNG EUGENE Y, TANIS VIRGINIA M, WIENER JOHN J. M, KEARNEY AARON M, BACANI GENESIS M, LEE-DUTRA ALICE, WICKBOLDT ALVAH T, CHROVIAN CHRISTA C, LIANG JIMMY T, MANI NEELAKANDHA S, SEPASSI KIA, GOMEZ LAURENT, BROGGINI DIEGO, GRICE CHERYL A, SANTILLAN ALEJANDRO
Format: Patent
Sprache:eng ; slv
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.