PEGYLATED AMYLOID BETA FAB

A method to treat conditions associated with A² peptide activity both prophylactically and therapeutically is described. The method employs humanized antibody fragments that specifically bind human A² peptide between amino acid positions 13-28, wherein the antibody fragments are covalently attached...

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Hauptverfasser: DEMATTOS RONALD BRADLEY, LU JIRONG, BALES KELLY RENEE, CHOW CHI-KIN, BUMOL THOMAS FRANK, HANSEN RYAN JOHN, MCDONNELL PETER COLON, KUCHIBHOTLA UMA
Format: Patent
Sprache:eng ; slv
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Zusammenfassung:A method to treat conditions associated with A² peptide activity both prophylactically and therapeutically is described. The method employs humanized antibody fragments that specifically bind human A² peptide between amino acid positions 13-28, wherein the antibody fragments are covalently attached to a polyethylene glycol (PEG) molecule.