A CONTROLLED RELEASE FORMULATION FOR POORLY SOLUBLE BASIC DRUGS

A CONTROLLED RELEASE FORMULATION FOR POORLY SOLUBLE BASIC DRUGS

Controlled-release, solid, pharmaceutical compositions adapted for oral administration comprises: (a) at least one basic drug with a water solubility of less than 1 part per 30 parts water; (b) a water-soluble alginate salt; (c) a complex salt of alginic acid; and (d) an organic carboxylic acid to f...

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Hauptverfasser: WITHERS BRIAN C, CARMODY ALAN F, FEELY LIAM C, BROAD NEVILLE W
Format: Patent
Sprache:eng
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator WITHERS BRIAN C
CARMODY ALAN F
FEELY LIAM C
BROAD NEVILLE W
description Controlled-release, solid, pharmaceutical compositions adapted for oral administration comprises: (a) at least one basic drug with a water solubility of less than 1 part per 30 parts water; (b) a water-soluble alginate salt; (c) a complex salt of alginic acid; and (d) an organic carboxylic acid to facilitate dissolution of the basic drug. An Independent claim is also included for a controlled release solid pharmaceutical composition (I) adapted for oral administration of a once-a-day dosage regimen and comprising (in mg): clarithromycin (500), sodium-calcium alginate (75-400) and citric acid (128).
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title A CONTROLLED RELEASE FORMULATION FOR POORLY SOLUBLE BASIC DRUGS
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