PROCESS FOR THE PREPARATION OF Y(1R), 2S -2-AMINOPROPIONIC ACID 2-Y4-(4-FLUORO-2-METHYL-1H-INDOL-5-YLOXY)-5-METHYLPYRROLOY2,1-f Y1,2,4 TRIAZIN-6-YLOXY -1-METHYLETHYL ESTER

PROCESS FOR THE PREPARATION OF Y(1R), 2S -2-AMINOPROPIONIC ACID 2-Y4-(4-FLUORO-2-METHYL-1H-INDOL-5-YLOXY)-5-METHYLPYRROLOY2,1-f Y1,2,4 TRIAZIN-6-YLOXY -1-METHYLETHYL ESTER

The invention relates to an improved process for preparing [(1R), 2S]-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]-1-methylethyl ester of the formula: Compound I has been shown to be useful for the treatment of certain types of cancer.

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Bibliographische Detailangaben
Hauptverfasser: LEAHY DAVID K, LOBBEN PAUL C, THORNTON JOHN E, MUSLEHIDDINOGLU JALE, HAMEDI MOURAD, XU ZHONGMIN, DISCORDIA ROBERT P, LAI CHIAJEN, CRISPINO GERARD A, PESTI JAAN A, SPANGLER LORI ANN, LAPORTE THOMAS L
Format: Patent
Sprache:eng ; slv
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:The invention relates to an improved process for preparing [(1R), 2S]-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]-1-methylethyl ester of the formula: Compound I has been shown to be useful for the treatment of certain types of cancer.