Antitumoral pharmaceutical composition containing polypeptide fragments of serralysins

The present invention is related to a composition capable of inhibiting the growth of tumoral cells of different histological origins and of activated endothelial cells. The components of said compositions are polypeptide fragments of the serralisins, corresponding to the C-terminal fragment, from t...

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Hauptverfasser: GONZALEZ LOPEZ LUIS JAVIER CALLE 186, CASTELLANOS SERRA LILA ROSA KOHLY 51, SELMAN-HOUSEIN SOSA MANUEL, GARCIA SUAREZ JOSE CALLE 186, GOMEZ RIERA RAUL, REYES GONZALEZ JESUS CALLE 186, VELIZ RIOS GLORIA CALLE 140, GASMURI GONZALEZ CARIDAD ANAIS, MARTINEZ DIAZ EDUARDO CALLE 186, ABRAHANTES PEREZ MARIA DEL CARMEN CALLE 186, GAVILONDO COWLEY JORGE VICTOR CALLE G, BEQUET ROMERO MONICA
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Sprache:eng ; slv
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Zusammenfassung:The present invention is related to a composition capable of inhibiting the growth of tumoral cells of different histological origins and of activated endothelial cells. The components of said compositions are polypeptide fragments of the serralisins, corresponding to the C-terminal fragment, from the internal metionine trough the end of the molecule, which could be combined among them and optionally with the prodigiosins that potentiate the antitumoral effect of the composition. The prodigiosins in the composition could be at a concentration of 0.1 - 100 nM. The anti-proliferative action of this composition is mediated by apoptotic mechanism. It's "in vivo" administration has antitumoral, antiangiogenic and protective effect against malignant tumors.