C-substituted cyclohexylmethylamine derivatives

Substituted cyclohexylmethyl-amine derivatives (I), optionally as racemates, pure or mixed stereoisomers (especially enantiomers and diastereomers), salts with acids or bases and/or solvates, especially hydrates. Substituted cyclohexylmethyl-amine derivatives of formula (I), optionally as racemates,...

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Bibliographische Detailangaben
Hauptverfasser:	SUNDERMANN CORINNA DR, KOGEL BABETT-YVONNE DR, BUSCHMANN HELMUT DR, FINKAM MICHAEL DR, SUNDERMANN BERND DR
Format:	Patent
Sprache:	eng ; slv
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Substituted cyclohexylmethyl-amine derivatives (I), optionally as racemates, pure or mixed stereoisomers (especially enantiomers and diastereomers), salts with acids or bases and/or solvates, especially hydrates. Substituted cyclohexylmethyl-amine derivatives of formula (I), optionally as racemates, pure or mixed stereoisomers (especially enantiomers and diastereomers), salts with acids or bases and/or solvates, especially hydrates are new A : hydrogen or (hetero)aryl, optionally substituted one or more times; R 1>1-10C alkyl or 3-10C cycloalkyl, optionally unsaturated, linear or branched and substituted one or more times; (hetero)aryl, or (hetero)aryl or 3-10C cycloalkyl connected through 1-3C alkyl (optionally unsaturated), 1-3C alkylene or ethynyl, all optionally substituted one or more times by fluoro, chloro, bromo, iodo, OR 1> 8>, SR 1> 8>, SO 2R 1> 8>, SO 2OR 1> 8>, cyano, COOR 1> 8>, NR 1> 9>R 2> 0>, 1-10C alkyl, 3-10C cycloalkyl or silyl (optionally substituted one or more times), (hetero)aryl (optionally substituted one or more times), or (hetero)aryl or 3-10C cycloalkyl, connected through 1-3C alkyl (optionally unsaturated) or 1-3C alkylene; R 1> 8>, R 1> 9> and R 2> 0>hydrogen, 1-10C alkyl or 3-10C cycloalkyl, optionally unsaturated, linear or branched and substituted one or more times; (hetero)aryl, or (hetero)aryl or 3-10C cycloalkyl connected through 1-3C alkyl (optionally unsaturated) or 1-3C alkylene, or R 1> 9> and R 2> 0> are together CH 2CH 2[O or R 2> 1>]CH 2CH 2, or (CH 2) z; z : 3-6; R 2> 1>hydrogen, optionally substituted phenyl or 1-10C alkyl, saturated or unsaturated, linear or branched, optionally substituted one or more times; R 2> and R 3>as defined for R 1> 8>, or together form a ring as for R 1> 9> and R 2> 0>; X completes one of the partial structures B = hydroxy, OR 7>, hydrogen, fluoro, chloro or NR 8>R 9>; R 7> = R 1> 8> but not hydrogen; R 8> and R 9> are as R 1> 8> or together form a ring as R 1> 9> and R 2> 0>; Z-Y = any of five specified groups; some compounds are excluded by provisos . The full definitions are given in the DEFINITIONS (Full Definitions) Field. ACTIVITY : Analgesic. No details of tests for analgesic activity are given. MECHANISM OF ACTION : None given in the source material.