PROCESS FOR PRODUCING CILOSTAZOL

The present invention provides a process for producing cilostazol ÄIÜ in a high yield and a high purity, by reacting a carbostyril derivative ÄIIÜ with a tetrazole derivative ÄIIIÜ in the presence of an inorganic basic compound in a solvent of water, wherein water is used in an amount of 3 to 7-fold...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: YAMAMOTO AKIHIRO, FUKUYAMA NORIHIRO, TOMINAGA MICHIAKI, MIYAMOTO HISASHI, OKAICHI YOSHIHIKO, YAMADA YASUHIRO
Format: Patent
Sprache:eng ; slv
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Beschreibung
Zusammenfassung:The present invention provides a process for producing cilostazol ÄIÜ in a high yield and a high purity, by reacting a carbostyril derivative ÄIIÜ with a tetrazole derivative ÄIIIÜ in the presence of an inorganic basic compound in a solvent of water, wherein water is used in an amount of 3 to 7-fold weight to that of the carbostyril derivative ÄIIÜ and the inorganic basic compound is used in an amount of 1 to 6 mol per mol of the carbostyril derivative ÄIIÜ. The process of the present invention is the improved and environment-friendly process for producing cilostazol being useful for pharmaceuticals.