Process for the preparation of nicotinic acid amide

Preparation of nicotinamide (I) comprises: (a) converting 2-methyl-1,5-diamino-pentane to 3-methylpyridine (III) which is then converted to 3-picoline (IV); (b) treating (IV) in presence of ammonia and oxygen-containing gas at 280-400 degrees C over an ammonia oxidation catalyst (A) to form 3-cyanop...

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Bibliographische Detailangaben
Hauptverfasser:	DETTWILER HANS-RUDOLF DR, ARMBRUSTER ERICH DR, CHUCK RODERICK JOHN DR, HEVELING JOSEF DR, ROHNER MARKUS DR, UTIGER LUKAS DR
Format:	Patent
Sprache:	eng ; slv
Schlagworte:	BEER BIOCHEMISTRY CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HETEROCYCLIC COMPOUNDS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PROCESSES USING MICROORGANISMS SPIRITS THEIR RELEVANT APPARATUS TRANSPORTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	Preparation of nicotinamide (I) comprises: (a) converting 2-methyl-1,5-diamino-pentane to 3-methylpyridine (III) which is then converted to 3-picoline (IV); (b) treating (IV) in presence of ammonia and oxygen-containing gas at 280-400 degrees C over an ammonia oxidation catalyst (A) to form 3-cyanopyridine (V) and (c) converting (V) to (I) using a microorganism of the genus Rhodococcus. (II) is converted to (III) in the gas phase at 300-400 degrees C and 0-10 bar excess pressure by passage over a catalyst containing as active component ≥ 1 oxide of aluminium and/or silicon, having a surface ratio of acid:basic centres > 2 and specific surface > 40 m /g. Conversion to (IV) is done immediately at 220-400 degrees C over a dehydrogenation catalyst. (A) comprises oxides of vanadium, titanium, zirconium and molybdenum in mole ratio V2O5:TiO2:ZrO2 of 1:1:2-1:12:35 and of MoO3 content, based on V2O5, of 0.54-2.6wt.%. The steps (b) and (c) are claimed together as a distinct process.