4-Phenyl-3-substituted 1,4-dihydropyridine esters with cerebral activity

4-Phenyl-3-substituted 1,4-dihydropyridine esters with cerebral activity

4-Phenyl 3-substituted 1,4-dihydropyridine esters are prepared by reacting benzaldehydes with keto esters and enamines, where appropriate with isolation of ylidene intermediates, or by esterification of corresponding dihydropyridinecarboxylic acids with alcohols. The 4-phenyl 3-substituted 1,4-dihyd...

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Hauptverfasser: SCHUURMAN TEUNIS DR, SCHOHE-LOOP RUDOLF DR, GAO ZHAN DR, SCHMIDT BERNARD DR, MEIER HEINRICH DR, HARTWIG WOLFGANG DR, JUNGE BODO DR, DE JONGE MAARTEN DR
Format: Patent
Sprache:eng ; slv
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:4-Phenyl 3-substituted 1,4-dihydropyridine esters are prepared by reacting benzaldehydes with keto esters and enamines, where appropriate with isolation of ylidene intermediates, or by esterification of corresponding dihydropyridinecarboxylic acids with alcohols. The 4-phenyl 3-substituted 1,4-dihydropyridine esters can be used as active ingredients in pharmaceuticals for the treatment of the central nervous system, in particular as cerebral therapeutic agents.