1H-indole-3-acetic acid hydrazide sPLA2 inhibitors

A class of 1H-indole-3-acetic acid hydrazides, represented by the formula (I) is disclosed together with the use of such indole compounds for inhibiting sPLA2 mediated release of fatty acids (e.g., arachidonic acid) for treatment of conditions such as septic shock.

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Bibliographische Detailangaben
Hauptverfasser:	DILLARD ROBERT DELANE, SCHEVITZ RICHARD WALTER, HERMANN ROBERT BELL, DRAHEIM SUSAN ELIZABETH, BACH NICHOLAS JAMES
Format:	Patent
Sprache:	eng ; slv
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	A class of 1H-indole-3-acetic acid hydrazides, represented by the formula (I) is disclosed together with the use of such indole compounds for inhibiting sPLA2 mediated release of fatty acids (e.g., arachidonic acid) for treatment of conditions such as septic shock.