PROCESS FOR THE PREPARATION OF RETIGABINE

PROCESS FOR THE PREPARATION OF RETIGABINE

This invention relates to a novel chemical process for the synthesis of 2-ethyoxycarbonylamino-5-(4-fluorobenzylamino)-nitrobenzene and its use in the preparation of 2-amino-4-(4-fluorobenzylamino)-1-ethoxycarbonylaminobenzene (retigabine/ezogabine) and its polymorphic forms thereof.

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Bibliographische Detailangaben
Hauptverfasser: MILLAR, ALAN, TOCZKO, JENNIFER, FELL, FITZGERALD, RUSS, N
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:This invention relates to a novel chemical process for the synthesis of 2-ethyoxycarbonylamino-5-(4-fluorobenzylamino)-nitrobenzene and its use in the preparation of 2-amino-4-(4-fluorobenzylamino)-1-ethoxycarbonylaminobenzene (retigabine/ezogabine) and its polymorphic forms thereof.