DNA POLYMERASES WITH INCREASED 3'-MISMATCH DISCRIMINATION

DNA POLYMERASES WITH INCREASED 3'-MISMATCH DISCRIMINATION

Disclosed are mutant DNA polymerases having increased 3 '-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acid...

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Hauptverfasser: BAUER, KEITH, A, MYERS, THOMAS, W, REICHERT, FRED, L, SAN FILIPPO, JOSEPH, SCHOENBRUNNER, NANCY, J
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creator BAUER, KEITH, A
MYERS, THOMAS, W
REICHERT, FRED, L
SAN FILIPPO, JOSEPH
SCHOENBRUNNER, NANCY, J
description Disclosed are mutant DNA polymerases having increased 3 '-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases.
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title DNA POLYMERASES WITH INCREASED 3'-MISMATCH DISCRIMINATION
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