ANTIBODIES AGAINST HUMAN INTERLEUKIN-13 AND USES THEREFOR

This application relates to antibodies, e.g ., humanized antibodies, and antigen-binding fragments thereof, that bind to interleukin-13 (IL-13), in particular, human IL-13, and their uses in regulating immune responses mediated by IL-13. The antibodies disclosed herein are useful in diagnosing, prev...

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Bibliographische Detailangaben
Hauptverfasser:	GOLDMAN SAMUEL J, VELDMAN GEERTRUIDA M, DONALDSON DEBRA D, MARQUETTE KIMBERLY ANN, FEYFANT ERIC, KASAIAN MARION T, LIN LAURA LONG, TCHISTIAKOVA LIOUDMILA, TAN XIANG-YANG, WOOD NANCY L, TAM AMY SZEPUI, WIDOM ANGELA M, SHANE TANIA, PARRIS KEVIN D, FITZ LORI J
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	This application relates to antibodies, e.g ., humanized antibodies, and antigen-binding fragments thereof, that bind to interleukin-13 (IL-13), in particular, human IL-13, and their uses in regulating immune responses mediated by IL-13. The antibodies disclosed herein are useful in diagnosing, preventing, and/or treating a subject, e.g., a human patient, one or more IL-13-associated disorders, e.g., respiratory disorders ( e.g., asthma); atopic disorders ( e.g ., allergic rhinitis); inflammatory and/or autoimmune conditions of the skin ( e.g., atopic dermatitis), and gastrointestinal organs ( e.g., inflammatory bowel diseases (IBD)), as well as fibrotic and cancerous disorders.