Process for the enzymatic preparation of enantiomerically enriched beta-amino acids

Production of enantiomerically enriched, N-unprotected beta-amino acids (I) comprises enzymatic hydrolysis of an enantiomeric mixture of N-unprotected beta-aminoacid esters (II) using a hydrolase, provided that (II) is other than a methyl or ethyl ester. An Independent claim is also included for new...

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Bibliographische Detailangaben
Hauptverfasser:	GROGER, HARALD, WERNER HELGE
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Production of enantiomerically enriched, N-unprotected beta-amino acids (I) comprises enzymatic hydrolysis of an enantiomeric mixture of N-unprotected beta-aminoacid esters (II) using a hydrolase, provided that (II) is other than a methyl or ethyl ester. An Independent claim is also included for new beta-aminoacid n-propyl esters of formula (II'). R = 1-8C alkyl, 2-8C alkenyl, 2-8C alkynyl, 3-8C cycloalkyl (optionally substituted by 1-3 1-8C alkyl), 6-18C aryl (optionally substituted by 1-3 1-8C alkyl), 7-19C aralkyl, 3-18C heteroaryl (optionally substituted by 1-3 1-8C alkyl) or 4-19C heteroaralkyl; and R' = H or as defined for R.