ANTIBODIES SPECIFIC FOR CD70 AND THEIR USES

ANTIBODIES SPECIFIC FOR CD70 AND THEIR USES

The present invention provides antibodies that specifically bind to CD70 (Cluster of Differentiation 70). The invention further provides bispecific antibodies that bind to CD70 and another antigen (e.g., CD3). The invention further relates to antibody encoding nucleic acids, and methods of obtaining...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: PANOWSKI, Siler, SAI, Tao, SRIVATSA SRINIVASAN, Surabhi, SASU, Barbra Johnson, VAN BLARCOM, Thomas John
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:The present invention provides antibodies that specifically bind to CD70 (Cluster of Differentiation 70). The invention further provides bispecific antibodies that bind to CD70 and another antigen (e.g., CD3). The invention further relates to antibody encoding nucleic acids, and methods of obtaining such antibodies (monospecific and bispecific). The invention further relates to therapeutic methods for use of these antibodies for the treatment of CD70-mediated pathologies, including cancer.